is a water-soluble, non-toxic, and fluorescent tricarbocyanine dye that has found widespread applications in medical diagnostics and research. Primarily used in the field of medicine, ICG is renowned for its unique optical properties, particularly its ability to absorb and emit light in the near-infrared (NIR) spectrum, which allows for deep tissue penetration and minimal autofluorescence interference from biological tissues.
In clinical settings, ICG is commonly employed as a contrast agent for various imaging modalities, including fluorescence angiography, which is invaluable in assessing blood flow dynamics and perfusion in real-time during surgical procedures. Surgeons utilize ICG-guided fluorescence imaging to visualize and identify vital anatomical structures, such as blood vessels and bile ducts, with exceptional clarity, enhancing surgical precision and minimizing the risk of complications.
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| C43H47N2NaO6S2 | |
| 774.28 | |
| 774.97 | |
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m/z |
774.28 (100.0%), 775.28 (46.5%), 776.28 (10.6%), 776.27 (9.0%), 777.28 (4.2%), 775.28 (1.6%), 776.28 (1.2%) |
| C, 66.64; H, 6.11; N, 3.61; Na, 2.97; O, 12.39; S, 8.27 |
is a powerful fluorescent dye with diverse applications in medical imaging, photothermal therapy, biorecognition, drug delivery, and more. Its unique properties, including rapid vascular distribution, liver clearance, and near-infrared fluorescence, have made it an essential tool in modern medicine and biomedical research.
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- When illuminated with near-infrared light, ICG emits fluorescence that can be captured by specialized imaging equipment, allowing for the visualization of blood vessels' morphology and structure. This technique is crucial in diagnosing and treating vascular diseases.
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- Photothermal therapy utilizes the ability of ICG to absorb near-infrared light and convert it into heat, causing localized thermal destruction of tumor cells. This targeted approach minimizes damage to surrounding healthy tissues, making it a promising technique in cancer treatment.
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- As part of drug delivery systems, ICG can encapsulate drugs within its molecular structure. The drugs can then be released upon activation by near-infrared light, enabling precise targeting of disease sites and improving treatment efficacy.
- : ICG's fluorescence properties make it an attractive choice for high-resolution, high-contrast imaging, providing non-invasive and real-time information to medical professionals.
ICG is a cyanine dye with a high absorption and emission wavelength in the infrared range (780nm-800nm). This allows it to penetrate deeper into tissues compared to other commonly used fluorescent dyes, making it particularly suitable for vascular imaging.
Upon intravenous injection, ICG quickly binds to plasma proteins and distributes throughout the bloodstream, enabling efficient visualization of the vascular system. It is considered a low-toxicity fluorescent agent with minimal side effects.
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ICG-based angiography, also known as ICG vascular imaging, is a non-invasive technique that allows for real-time visualization of blood flow in the cardiovascular system. This is particularly useful in detecting abnormalities such as stenosis, occlusion, or collateral vessel formation.
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Real-Time Imaging
ICG-based imaging provides real-time visualization of blood flow, enabling prompt identification of abnormalities.
Compared to traditional diagnostic methods, ICG-based angiography is less invasive and carries lower risks.
is a versatile dye widely used in medical applications, particularly in the fields of ophthalmology, cardiology, and hepatology. Its near-infrared fluorescence properties make it ideal for visualizing blood flow and assessing organ function non-invasively. However, when using ICG, several precautions should be observed to ensure patient safety and accurate diagnostic outcomes.
- Secondly, dosage must be carefully calculated based on patient-specific factors such as weight, age, and underlying conditions. Excessive doses can lead to adverse effects, including skin discoloration and potential toxicity to the retina.
In conclusion, while ICG offers significant advantages in medical diagnosis and surgery, its use requires strict adherence to safety protocols and careful consideration of patient-specific factors to ensure optimal outcomes.
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